Kennedy’s Disease refers to Spinal and Bulbar Muscular Atrophy (SBMA) and is a rare type of inherited disease that affects the neurons (more commonly known as nerve cells) in the brain.1
Kennedy’s Disease is named after William R. Kennedy who reported seeing this disease in patients in 1968.1
It is estimated that around 1 to 2 per 100,000 people worldwide has Kennedy’s Disease, although the number may be higher due to difficulties with making a definitive diagnosis.1
The disease is characterised by the degeneration of lower motor neurons of the brainstem and spinal cord.2 This results in the muscles of the face and limbs becoming weaker and wasting away.3 The loss of muscle strength eventually leads to weakness in muscles throughout the body which makes movement difficult, particularly in the legs and arms, and with speech and swallowing. Kennedy’s Disease more commonly affects men.
Other major symptoms of the disease include enlargement of breasts, muscle cramps and spasms, hand tremors, impotence and speech and swallowing difficulties.4 The symptoms can be managed, but there is no cure.5
Age of onset is usually between 35 and 40 years.1 The disease generally progresses slowly6 and does not usually impact life expectancy.7
A mutation in the androgen receptor gene (AR) is responsible for the disease.8 The androgen receptor gene is located on the X chromosome9 and helps to control the activity of male sex hormones (androgens).
Men who inherit the mutated androgen receptor gene develop the disease. The mutated gene is present on the X chromosome, which is one of two chromosomes that decide the sex of a human. Men have X and Y chromosomes.10
Women have two X chromosomes.10 Women who inherit the mutated gene also carry it on their X chromosome. The impact of the normal gene on the other X chromosome usually overrides the mutated gene so this makes it rare for a woman to develop the disease. Women who have inherited the mutated gene are carriers of the disease.1 Each son of a woman who is a carrier has a 50% chance of inheriting the gene and developing the disease.1
Kennedy’s Disease is rare and can be misdiagnosed, often being mistaken for motor neurone disease (MND) as it shares a lot of similar symptoms. A thorough medical review is required to make an accurate diagnosis and includes assessment of the patient’s family history, symptoms and rate of progression. Tests11 used to confirm a diagnosis of Kennedy’s Disease include:
The main similarity between Kennedy’s Disease and MND is the symptoms they display. Both diseases cause the weakening and wasting of muscles. While the wasting of muscles can make Kennedy’s Disease easy to mistake for MND, there are a number of significant differences between the diseases.
The differences are mainly to do with the age at when the diseases start, their genetic causes, the rate at which they occur, how fast they progress, their associated life expectancy and which gender is more commonly affected.
Currently, there is no cure for Kennedy’s Disease. Treatment aims to reduce and manage the symptoms. A healthy lifestyle that includes a balanced diet, gentle and regular aerobic exercise, getting plenty of rest and avoidance of exhaustion plays a big part in daily management of the condition. Regular stretching to help reduce muscle cramping is also useful. Other interventions11 include:
Talking with your General Practitioner (GP) is the best place to start if you have any suspicions that you may have Kennedy’s Disease. You will usually be referred to a Neurologist for further review and testing. If you do have Kennedy’s Disease your GP can help you access the health professionals you need as time goes on.
Female carriers of Kennedys Disease can receive genetic and fertility specialist advice to help reduce the chance of passing on the disease. MND state-based associations provide ongoing support through their Advisors. A place to find support from others affected by Kennedy’s Disease is via the private Facebook group Kennedys Disease Downunder.